Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29577769 | 0.91 | PDE10A (0.36) | GAKPDE10APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL20331744 | 0.91 | PDE10A (0.36) | GAKPDE10APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL21252164 | 0.86 | PDE10A (0.42) | PDE10APDE3BPDE3A | |
| SCHEMBL21252155 | 0.85 | GAK (0.36) | GAKPDE10APDE3BPDE3ALRRK2 | |
| SCHEMBL21252209 | 0.84 | NTSR1 (0.40) | GAKSMN1; SMN2ALDH1A1KDM4ESTAT6 | |
| SCHEMBL21252359 | 0.84 | NTSR1 (0.39) | PDE10APDE3BPDE3ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21251914 | 0.83 | MAP4K4 (0.40) | PDE10APDE3BPDE3ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21252502 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KDM4ESTAT6NPSR1 | |
| SCHEMBL21252491 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1KDM4ESTAT6NPSR1 | |
| SCHEMBL24488330 | 0.82 | HTT (0.36) | PDE10APDE3BPDE3ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |