Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.36 |
| ▸ | NEK2 | P51955 | 8/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240563 | 0.91 | FGFR4 (0.35) | GAKFGFR4TTKLRRK2FGFR1 | |
| SCHEMBL24488230 | 0.86 | PDE10A (0.39) | FGFR4NEK2FGFR1FGFR2PDE3B | |
| SCHEMBL20332233 | 0.86 | TTK (0.33) | GAKFGFR4TTKLRRK2FGFR1 | |
| SCHEMBL21252449 | 0.85 | TTK (0.38) | GAKNEK2TTKLRRK2FGFR1 | |
| SCHEMBL21251928 | 0.85 | GAK (0.38) | GAKTTKLRRK2PDE3BPDE3A | |
| SCHEMBL21252481 | 0.84 | FGFR4 (0.40) | FGFR4NEK2FGFR1FGFR2PLK1 | |
| SCHEMBL21252058 | 0.84 | FGFR4 (0.40) | FGFR4NEK2TTKFGFR1FGFR2 | |
| SCHEMBL21252087 | 0.83 | MAP4K4 (0.39) | FGFR4LRRK2FGFR1FGFR2PDE3B | |
| SCHEMBL21252286 | 0.82 | SMN1; SMN2 (0.40) | FGFR4FGFR1FGFR2 | |
| SCHEMBL21252341 | 0.82 | SMN1; SMN2 (0.43) | FGFR4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |