Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331105 | 0.94 | TTK (0.37) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL29577170 | 0.94 | TTK (0.37) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL20331101 | 0.89 | MEN1 (0.36) | FGFR4PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL20331792 | 0.88 | TTK (0.41) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL21252374 | 0.87 | PDE10A (0.35) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL20331785 | 0.87 | TTK (0.35) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL20331753 | 0.87 | FGFR4 (0.33) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL30046521 | 0.87 | FGFR4 (0.33) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL29578207 | 0.87 | FGFR4 (0.33) | TTKFGFR4PDE4BPDE4APDE4C | |
| SCHEMBL20331760 | 0.87 | FGFR4 (0.33) | TTKFGFR4PDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |