Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240454 | 0.95 | TTK (0.35) | TTKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30045226 | 0.95 | TTK (0.35) | TTKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21251942 | 0.94 | TTK (0.37) | TTKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21252374 | 0.91 | PDE10A (0.35) | TTKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20331968 | 0.89 | TTK (0.34) | TTKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30045422 | 0.89 | TTK (0.34) | TTKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20331101 | 0.89 | MEN1 (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL20331786 | 0.89 | TTK (0.33) | TTK | |
| SCHEMBL21252445 | 0.88 | TTK (0.36) | TTKFGFR4 | |
| SCHEMBL21252146 | 0.87 | TTK (0.37) | TTKPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |