Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 4/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24488354 | 0.94 | MAP4K4 (0.39) | FGFR1NEK2TTKFGFR2MAP3K12 | |
| SCHEMBL21251649 | 0.92 | FGFR1 (0.38) | FGFR1TTKFGFR2MAP3K12 | |
| SCHEMBL21252280 | 0.89 | TTK (0.38) | PDE10APDE3BPDE3ANEK2TTK | |
| SCHEMBL21252066 | 0.88 | FGFR1 (0.37) | FGFR1NEK2TTKFGFR2 | |
| SCHEMBL21252253 | 0.88 | TTK (0.38) | FGFR1NEK2TTKFGFR2MAP3K12 | |
| SCHEMBL20331964 | 0.87 | PDE10A (0.36) | PDE10APDE3BPDE3ANEK2TTK | |
| SCHEMBL29578107 | 0.87 | PDE10A (0.36) | PDE10APDE3BPDE3ANEK2TTK | |
| SCHEMBL21252525 | 0.86 | FGFR1 (0.36) | FGFR1TTKFGFR2MAP3K12 | |
| SCHEMBL21252444 | 0.86 | NEK2 (0.39) | FGFR1NEK2FGFR2SUV39H2 | |
| SCHEMBL21252449 | 0.86 | TTK (0.38) | FGFR1NEK2TTKFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |