Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 2/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24488354 | 0.93 | MAP4K4 (0.39) | TTKMAP4K4FGFR1NOS1FGFR2 | |
| SCHEMBL21252066 | 0.91 | FGFR1 (0.37) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL21252258 | 0.89 | NOS1 (0.42) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL21252169 | 0.88 | FGFR1 (0.38) | TTKMAP4K4FGFR1FGFR2NEK2 | |
| SCHEMBL21251649 | 0.84 | FGFR1 (0.38) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL21252431 | 0.83 | FGFR1 (0.38) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL21240312 | 0.81 | TTK (0.37) | TTKMAP4K4KDRFGFR1NOS1 | |
| SCHEMBL29578336 | 0.81 | TTK (0.37) | TTKMAP4K4KDRFGFR1NOS1 | |
| SCHEMBL24488373 | 0.81 | NOS1 (0.46) | TTKJAK2JAK1TYK2KDR | |
| SCHEMBL24488321 | 0.81 | NOS1 (0.44) | JAK2JAK1TYK2KDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |