Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 4/20 | 0.36 |
| ▸ | DCK | P27707 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251916 | 0.95 | TTK (0.39) | TTKNEK2DCKMAP4K4JAK2 | |
| SCHEMBL20330834 | 0.92 | TTK (0.37) | TTKMAP3K12NEK2JAK2JAK1 | |
| SCHEMBL21252169 | 0.89 | FGFR1 (0.38) | TTKMAP3K12NEK2PDE3BPDE3A | |
| SCHEMBL29578126 | 0.87 | TTK (0.37) | TTKMAP3K12NEK2PDE3BPDE3A | |
| SCHEMBL20331967 | 0.87 | TTK (0.37) | TTKMAP3K12NEK2PDE3BPDE3A | |
| SCHEMBL24488377 | 0.85 | NOS1 (0.44) | NEK2JAK2JAK1TYK2KDR | |
| SCHEMBL20331865 | 0.85 | PDE10A (0.37) | MAP3K12NEK2PDE3BPDE3APDE10A | |
| SCHEMBL21252186 | 0.84 | FFAR2 (0.43) | TTKMAP3K12 | |
| SCHEMBL21252314 | 0.83 | GAK (0.39) | MAP3K12JAK2JAK1TYK2KDR | |
| SCHEMBL24488354 | 0.83 | MAP4K4 (0.39) | TTKMAP3K12NEK2MAP4K4NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |