Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331471 | 0.88 | SMN1; SMN2 (0.51) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL30045467 | 0.88 | SMN1; SMN2 (0.51) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL21251923 | 0.88 | SMN1; SMN2 (0.51) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL21252206 | 0.87 | LRRK2 (0.42) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL21251933 | 0.86 | GAK (0.39) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL21251668 | 0.86 | NTSR1 (0.39) | PIK3CAMTORHIF1APDE10A | |
| SCHEMBL21252194 | 0.85 | PIK3CA (0.36) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL21252184 | 0.84 | PIK3CA (0.35) | PIK3CAMTORUSP2CYP1A2CYP3A4 | |
| SCHEMBL21252489 | 0.84 | KDM4E (0.48) | PIK3CAMTORMAPK1HPGDPIK3CD | |
| SCHEMBL21251903 | 0.84 | PDE10A (0.36) | PIK3CAMTORHPGDHIF1APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |