Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 12/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252187 | 0.88 | TTK (0.41) | TTKGAKMAP3K12JAK2JAK1 | |
| SCHEMBL24488400 | 0.88 | MAP3K12 (0.38) | TTKMAP3K12JAK2JAK1TYK2 | |
| SCHEMBL21240493 | 0.87 | TTK (0.38) | TTKGAK | |
| SCHEMBL29578139 | 0.87 | TTK (0.38) | TTKGAK | |
| SCHEMBL21251781 | 0.86 | JAK2 (0.36) | TTKMAP3K12JAK2JAK1TYK2 | |
| SCHEMBL21252086 | 0.86 | JAK2 (0.38) | TTKMAP3K12JAK2JAK1TYK2 | |
| SCHEMBL21252019 | 0.85 | TTK (0.37) | TTKGAKMAP3K12JAK2JAK1 | |
| SCHEMBL21252225 | 0.85 | NOS1 (0.45) | GAK | |
| SCHEMBL21252008 | 0.84 | GAK (0.37) | TTKGAKMAP3K12 | |
| SCHEMBL24488377 | 0.83 | NOS1 (0.44) | GAKJAK2JAK1TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |