Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251663 | 0.94 | NOS1 (0.36) | TTKNOS1FGFR1FGFR2JAK2 | |
| SCHEMBL24488375 | 0.89 | FGFR1 (0.35) | TTKNOS1FGFR1FGFR2JAK2 | |
| SCHEMBL21252442 | 0.89 | TTK (0.34) | TTKNOS1FGFR1FGFR2JAK2 | |
| SCHEMBL20331785 | 0.88 | TTK (0.35) | TTKFGFR4 | |
| SCHEMBL21252315 | 0.85 | TTK (0.38) | TTKNOS1FGFR1FGFR2 | |
| SCHEMBL21252039 | 0.85 | TTK (0.37) | TTKNOS1JAK2JAK1TYK2 | |
| SCHEMBL21252267 | 0.85 | PDE10A (0.36) | TTKNOS1FGFR1FGFR2JAK2 | |
| SCHEMBL21252273 | 0.85 | FGFR1 (0.35) | TTKNOS1FGFR1FGFR2JAK2 | |
| SCHEMBL20332031 | 0.83 | PDE9A (0.38) | TTKFGFR1FGFR2FGFR4 | |
| SCHEMBL20331978 | 0.83 | PDE9A (0.39) | TTKFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |