Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21257527 | 0.79 | MAPT (0.55) | MAPTNPC1RAB9AMAPK1NOTUM | |
| SCHEMBL3700956 | 0.77 | TP53 (0.53) | MAPTNPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL21257521 | 0.76 | MAPT (0.52) | MAPTNPC1RAB9AMAPK1NOTUM | |
| SCHEMBL19808418 | 0.71 | MAPT (0.57) | MAPTNPC1RAB9AMAPK1NPSR1 | |
| SCHEMBL17172478 | 0.71 | MAPK1 (0.60) | MAPTNPC1RAB9AMAPK1NOTUM | |
| SCHEMBL3701140 | 0.70 | TP53 (0.53) | MAPTNPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL11790767 | 0.70 | NPSR1 (0.55) | MAPTNPC1RAB9AMAPK1NOTUM | |
| SCHEMBL23113012 | 0.69 | SMN1; SMN2 (0.75) | MAPTNPC1RAB9AMAPK1NOTUM | |
| SCHEMBL18867935 | 0.69 | TSHR (0.74) | MAPTNPC1RAB9ANPSR1TSHR | |
| SCHEMBL2325118 | 0.69 | TSHR (0.74) | MAPTNPC1RAB9ANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019154366-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏奥赛康药业有限公司 | 2019-08-15 | — | — | WO | disclosed |