Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17518717 | 0.69 | PARP1 (0.42) | PARP1PARP15PARP3MAPTKDM4E | |
| SCHEMBL12102081 | 0.66 | ALDH1A1 (0.38) | PARP1PARP15PARP3MAPTKDM4E | |
| SCHEMBL14827803 | 0.65 | — | — | |
| SCHEMBL2042295 | 0.65 | — | — | |
| SCHEMBL3119493 | 0.64 | PARP1 (0.47) | PARP1PARP15PARP3CYP1A2HIF1A | |
| SCHEMBL20954817 | 0.62 | UHRF1 (0.42) | PARP1MAPTUHRF1ALDH1A1HPGD | |
| SCHEMBL18711836 | 0.62 | PARP1 (0.62) | PARP1PARP15PARP3MAPTKDM4E | |
| SCHEMBL9377703 | 0.61 | PARP1 (0.38) | PARP1PARP15PARP3MAPTKDM4E | |
| SCHEMBL15757443 | 0.59 | UHRF1 (0.42) | MAPTKDM4ECYP1A2HIF1AUHRF1 | |
| SCHEMBL30666618 | 0.59 | PARP1 (0.42) | PARP1PARP15PARP3MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019157146-A1 | ALPHA POLYGLUTAMATED ANTIFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |