Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | INMT | O95050 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381657 | 0.79 | SRC (0.39) | ALDH1A1L3MBTL1INMTPRKD1PRKD2 | |
| SCHEMBL7782104 | 0.71 | PARP1 (0.56) | PARP1PARP15PARP3ALDH1A1L3MBTL1 | |
| SCHEMBL12102081 | 0.71 | ALDH1A1 (0.38) | PARP1PARP15PARP3ALDH1A1L3MBTL1 | |
| SCHEMBL7784771 | 0.69 | PARP1 (0.50) | PARP1PARP15PARP3ALDH1A1L3MBTL1 | |
| SCHEMBL12102086 | 0.64 | PARP1 (0.37) | PARP1PARP15PARP3ALDH1A1L3MBTL1 | |
| SCHEMBL21259968 | 0.61 | PARP1 (0.38) | PARP1PARP15PARP3ALDH1A1L3MBTL1 | |
| SCHEMBL10281390 | 0.61 | ADORA3 (0.31) | — | |
| SCHEMBL12002288 | 0.57 | MEN1 (0.39) | ALDH1A1INMTRAB9A | |
| SCHEMBL12102042 | 0.57 | PARP1 (0.37) | PARP1PARP15PARP3ALDH1A1L3MBTL1 | |
| SCHEMBL17547289 | 0.57 | PARP1 (0.40) | PARP1PARP15PARP3ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327284-B1 | Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators | RIKER LABORATORIES INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5166343-A | Chemical intermediates for bronchodilators | RIKER LABORATORIES, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5089493-A | Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4981850-A | Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0327284-A2 | Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1989-08-09 | — | — | EP | disclosed |