Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27972080 | 0.89 | MAPT (0.70) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL4319460 | 0.84 | MAPT (0.59) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL15271381 | 0.81 | SIRT6 (0.81) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL6151230 | 0.81 | SIRT6 (0.81) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL378458 | 0.77 | MAPT (0.96) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL1851861 | 0.77 | MAPT (0.89) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL27907348 | 0.76 | MAPT (0.68) | MAPTALDH1A1POLBLMNAMEN1 | |
| SCHEMBL85552 | 0.76 | MAPT (1.00) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL7048817 | 0.76 | MAPT (0.85) | MAPTALDH1A1SIRT6POLBADRB1 | |
| SCHEMBL6607374 | 0.76 | MAPT (1.00) | MAPTALDH1A1SIRT6POLBADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348695-B1 | Derivatives of paraphenylene diamine with pyrrolidine groups substituted by cationic radicals and their use for dyeing keratinic fibre | OREAL (FR) | 2012-04-25 | — | — | EP | disclosed |
| EP-1378230-B1 | Para-phenylenediamine derivatives comprising a pyrrolidinyl group substituted by a cyclic radical and their use in colouring keratinic fibres | OREAL (FR) | 2007-11-14 | — | — | EP | disclosed |
| EP-1378230-A1 | Para-phenylenediamine derivatives comprising a pyrrolidinyl group substituted by a cyclic radical and their use in colouring keratinic fibres | L'OREAL (FR) | 2004-01-07 | — | — | EP | disclosed |
| EP-1348695-A1 | Derivatives of paraphenylene diamine with pyrrolidine groups substituted by cationic radicals and their use for dyeing keratinic fibre | L'OREAL (FR) | 2003-10-01 | — | — | EP | disclosed |