Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851861 | 0.98 | MAPT (0.89) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL378458 | 0.94 | MAPT (0.96) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL6151230 | 0.94 | SIRT6 (0.81) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL15271381 | 0.94 | SIRT6 (0.81) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL85552 | 0.92 | MAPT (1.00) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL6607374 | 0.92 | MAPT (1.00) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL223626 | 0.92 | MAPT (1.00) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL3569406 | 0.90 | LMNA (1.00) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL7987707 | 0.90 | MAPT (0.70) | MAPTLMNASIRT6POLBALDH1A1 | |
| SCHEMBL12952781 | 0.86 | SIRT6 (0.71) | MAPTLMNASIRT6POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966449-B1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AND THEIR USE IN HAIR OXIDATION DYES | HENKEL KGAA (DE) | 2003-04-16 | — | — | EP | disclosed |
| US-6165230-A | 1,4-diazacycloheptane derivatives and their use in hair oxidation dyes | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2000-12-26 | — | — | US | disclosed |
| EP-0966449-A1 | NOVEL 1,4-DIAZACYCLOHEPTANE DERIVATIVES AND THEIR USE IN HAIR OXIDATION DYES | Henkel Kommanditgesellschaft auf Aktien (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038175-A1 | NOVEL 1,4-DIAZACYCLOHEPTANE DERIVATIVES AND THEIR USE IN HAIR OXIDATION DYES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1998-09-03 | — | — | WO | disclosed |