Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778633 | 0.86 | NPC1 (0.44) | CHRNA7HTR3ACHRNB4CHRNA3KDM4E | |
| SCHEMBL2126814 | 0.79 | CYP1A2 (0.50) | CHRNB4CHRNA3MEN1ALDH1A1KMT2A | |
| SCHEMBL2124934 | 0.78 | CHRNA7 (0.53) | CHRNA7 | |
| SCHEMBL5111037 | 0.77 | CHRNA7 (0.51) | CHRNA7HTR3ACHRNB4CHRNA3KDM4E | |
| SCHEMBL2124990 | 0.74 | ACHE (0.49) | CHRNA7KDM4ENPC1MAPTRAB9A | |
| SCHEMBL5109973 | 0.74 | CHRNA7 (0.50) | CHRNA7HTR3ACHRNB4CHRNA3KDM4E | |
| SCHEMBL5832115 | 0.72 | CHRNA7 (0.55) | CHRNA7HTR3ACHRNB4CHRNA3KDM4E | |
| SCHEMBL1752797 | 0.72 | CHRNA7 (0.66) | CHRNA7HTR3ACHRNB4CHRNA3KDM4E | |
| SCHEMBL6201547 | 0.72 | CHRNA7 (0.74) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL5112373 | 0.72 | CHRNA7 (0.48) | CHRNA7HTR3ACHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443122-A1 | DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145208-A1 | DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-12-23 | — | — | WO | disclosed |