Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | DAO | P14920 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28922916 | 0.91 | MTNR1A (0.59) | MTNR1ADAOPARP1ESR1POLB | |
| SCHEMBL114693 | 0.84 | MTNR1A (0.57) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL5779450 | 0.80 | MTNR1A (0.60) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL8135642 | 0.80 | MTNR1A (0.56) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL7015284 | 0.80 | FFAR1 (0.52) | MTNR1AITGB3ITGAVITGB5LMNA | |
| SCHEMBL30462513 | 0.78 | MTNR1A (0.57) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL2843620 | 0.77 | MTNR1A (0.64) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL8134945 | 0.77 | MTNR1A (0.56) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL8827650 | 0.77 | MTNR1A (0.56) | MTNR1ADAOPARP1P2RX7SLC22A12 | |
| SCHEMBL7771626 | 0.77 | MTNR1A (0.60) | MTNR1ADAOPARP1P2RX7SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443115-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145201-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |