SCHEMBL21272606

SCHEMBL21272606

COC[C@H](N)c1cccc(OC(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 1/20 0.41
SCN4A P35499 2/20 0.40
SLC6A2 P23975 6/20 0.40
TACR1 P25103 1/20 0.39
TRPM8 Q7Z2W7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21272608 1.00 GNRHR (0.41) GNRHRSCN4ASLC6A2TACR1TRPM8
Hydrochloric Acid SCHEMBL28715422 0.98 SLC6A2 (0.41) GNRHRSCN4ASLC6A2
Hydrochloric Acid SCHEMBL28715420 0.98 SLC6A2 (0.41) GNRHRSCN4ASLC6A2
SCHEMBL22952644 0.87 TACR1 (0.40) GNRHRSCN4ASLC6A2TACR1
SCHEMBL22965301 0.87 TACR1 (0.40) GNRHRSCN4ASLC6A2TACR1
SCHEMBL22953366 0.86 SCN4A (0.41) SCN4ASLC6A2TACR1TRPM8
SCHEMBL22965295 0.86 SCN4A (0.41) SCN4ASLC6A2TACR1TRPM8
Hydrochloric Acid SCHEMBL28719359 0.85 SLC6A2 (0.40) GNRHRSCN4ASLC6A2TACR1
Hydrochloric Acid SCHEMBL28719363 0.85 SLC6A2 (0.40) GNRHRSCN4ASLC6A2TACR1
Hydrochloric Acid SCHEMBL28702853 0.85 SCN4A (0.40) SCN4ASLC6A2TRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4007571-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS FOR USE IN EPILEPSY OR SEIZURES H LUNDBECK AS (DK) 2025-06-18 EP disclosed
EP-4241843-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H LUNDBECK AS (DK) 2025-05-21 EP disclosed
US-12258305-B2 Alcohol derivatives as Kv7 potassium channel openers H. LUNDBECK A/S (DK) 2025-03-25 US disclosed
CN-119490430-A Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures H.隆德贝克有限公司 2025-02-21 CN disclosed
CN-114206328-B Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures H.隆德贝克有限公司 2024-09-17 CN disclosed
EP-4241843-A2 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. Lundbeck A/S (DK) 2023-09-13 EP disclosed
EP-4241843-A2 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. Lundbeck A/S (DK) 2023-09-13 EP disclosed
CN-116589375-A Alcohol derivatives as Kv7 potassium channel openers H.隆德贝克有限公司 2023-08-15 CN disclosed
EP-3755684-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H LUNDBECK AS (DK) 2023-07-12 EP disclosed
EP-3755684-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H LUNDBECK AS (DK) 2023-07-12 EP disclosed
WO-2021023617-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2021-02-11 WO disclosed
US-20210032196-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2021-02-04 US disclosed
CN-111727182-A Alcohol derivatives as Kv7 potassium channel openers H.隆德贝克有限公司 2020-09-29 CN disclosed
US-20200172474-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2020-06-04 US disclosed
US-20200172474-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2020-06-04 US disclosed
US-10590067-B2 Alcohol derivatives of carboxamides as Kv7 potassium channel openers H. LUNDBECK A/S (DK) 2020-03-17 US disclosed
WO-2019161877-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2019-08-29 WO disclosed
US-20190256456-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2019-08-22 US disclosed
US-20190256456-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2019-08-22 US disclosed
US-20160158132-A1 Stabilization of Cosmetic Compositions BASF SE (DE) 2016-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160158132-A1 Stabilization of Cosmetic Compositions C1R, CBR1, CBR3 GNRHR 1064/4885SCN4A 1550/4885SLC6A2 2842/4885
US-20190256456-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS KCNA7, KCNK17, KCNQ1 GNRHR 3573/4885SCN4A 67/4885SLC6A2 396/4885
US-10590067-B2 Alcohol derivatives of carboxamides as Kv7 potassium channel openers KCNA7, KCNQ5, KCNQ1 GNRHR 4232/4885SCN4A 82/4885SLC6A2 1191/4885
US-20210032196-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS KCNA7, KCNK17, KCNQ1 GNRHR 3573/4885SCN4A 67/4885SLC6A2 396/4885
US-20200172474-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS KCNA7, KCNK17, KCNQ1 GNRHR 3573/4885SCN4A 67/4885SLC6A2 396/4885
US-12258305-B2 Alcohol derivatives as Kv7 potassium channel openers KCNA7, KCNK17, KCNQ1 GNRHR 3573/4885SCN4A 67/4885SLC6A2 396/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.