SCHEMBL21274147

SCHEMBL21274147

CCCC[Sn](CCCC)(CCCC)c1cnc(C=O)c(OC)n1

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30901452 1.00 CCR4 (0.32) CCR4
SCHEMBL3793452 0.72 CYP1A2 (0.40)
SCHEMBL29952590 0.70 KCNJ1 (0.38) CCR4
SCHEMBL1474575 0.70 KCNJ1 (0.38) CCR4
SCHEMBL6057013 0.69 POLB (0.37)
SCHEMBL29955754 0.69 POLB (0.37)
SCHEMBL21552078 0.68 SIRT6 (0.35)
SCHEMBL4626756 0.68 TXNRD1 (0.34)
SCHEMBL21274185 0.67 CCR4 (0.42) CCR4
SCHEMBL21274427 0.67 KCNJ1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270195-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES INC (US) 2025-08-28 US disclosed
US-12338233-B2 PD-1/Pd-L1 inhibitors GILEAD SCIENCES, INC. (US) 2025-06-24 US disclosed
CN-118084940-A PD-1/PD-L1 inhibitors 吉利德科学公司 2024-05-28 CN disclosed
EP-4227302-A1 PD-1/PD-L1 INHIBITORS Gilead Sciences, Inc. (US) 2023-08-16 EP disclosed
US-20230212155-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. 2023-07-06 US disclosed
EP-3752501-B1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES INC (US) 2023-04-19 EP disclosed
US-11555029-B2 PD-1/PD-L1 inhibitors GILEAD SCIENCES, INC. (US) 2023-01-17 US disclosed
US-20210053946-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. (US) 2021-02-25 US disclosed
EP-3752501-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. (US) 2020-12-23 EP disclosed
CN-111712494-A PD-1/PD-L1 inhibitors 吉利德科学公司 2020-09-25 CN disclosed
US-10710986-B2 PD-1/PD-L1 inhibitors GILEAD SCIENCES, INC. (US) 2020-07-14 US disclosed
US-20190270727-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. 2019-09-05 US disclosed
WO-2019160882-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. (US) 2019-08-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11555029-B2 PD-1/PD-L1 inhibitors PDCD1, CD274, PDCD1LG2 CCR4 960/4885
US-20230212155-A1 PD-1/PD-L1 INHIBITORS PDCD1, CD274, PDCD1LG2 CCR4 960/4885
US-12338233-B2 PD-1/Pd-L1 inhibitors PDCD1, CD274, PDCD1LG2 CCR4 960/4885
US-20210053946-A1 PD-1/PD-L1 INHIBITORS PDCD1, CD274, PDCD1LG2 CCR4 960/4885
US-20250270195-A1 PD-1/PD-L1 INHIBITORS PDCD1, CD274, PDCD1LG2 CCR4 960/4885
US-10710986-B2 PD-1/PD-L1 inhibitors PDCD1, CD274, PDCD1LG2 CCR4 960/4885
US-20190270727-A1 PD-1/PD-L1 INHIBITORS PDCD1, CD274, PDCD1LG2 CCR4 960/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.