Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.41 |
| ▸ | HRH2 | P25021 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276763 | 0.77 | HRH3 (0.54) | HRH2HRH1HRH3ACACBCHRM1 | |
| SCHEMBL18781559 | 0.76 | ACACB (0.39) | MCHR1ACACBKDM4ESMN1; SMN2 | |
| SCHEMBL17447653 | 0.75 | RET (0.49) | — | |
| SCHEMBL21276803 | 0.69 | MCHR1 (0.46) | MCHR1HRH2HRH1HRH3CHRM1 | |
| SCHEMBL21276772 | 0.69 | MCHR1 (0.39) | MCHR1ACACB | |
| SCHEMBL21276704 | 0.68 | ACACB (0.53) | MCHR1HRH2HRH1HRH3LTA4H | |
| SCHEMBL21276669 | 0.66 | HRH3 (0.42) | HRH2HRH1HRH3 | |
| SCHEMBL21276770 | 0.65 | MCHR1 (0.50) | MCHR1HRH2HRH1HRH3LTA4H | |
| SCHEMBL21276670 | 0.65 | MCHR1 (0.50) | MCHR1HRH2HRH1HRH3LTA4H | |
| SCHEMBL11402037 | 0.65 | LTA4H (0.49) | HRH2HRH1HRH3LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169671-B1 | 1-(5-(TERT.-BUTYL)ISOXAZOL-3-YL)-3-(4-((PHENYL)ETHYNYL)PHENYL)UREA DERIVATIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATING CANCER | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |