Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.42 |
| ▸ | HRH2 | P25021 | 8/20 | 0.42 |
| ▸ | HRH1 | P35367 | 8/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276708 | 0.83 | HRH3 (0.59) | HRH3HRH2HRH1EPHX2KCNH2 | |
| SCHEMBL21276772 | 0.82 | MCHR1 (0.39) | — | |
| SCHEMBL18763462 | 0.81 | HRH3 (0.44) | HRH3HRH2HRH1KCNH2 | |
| SCHEMBL21276739 | 0.79 | RAB9A (0.51) | HRH3HRH2HRH1EPHX2 | |
| SCHEMBL21276801 | 0.76 | HRH3 (0.55) | HRH3HRH2HRH1KCNH2 | |
| SCHEMBL21757567 | 0.76 | HRH3 (0.63) | HRH3HRH2HRH1EPHX2KCNH2 | |
| SCHEMBL18763407 | 0.75 | LTA4H (0.48) | HRH3HRH2HRH1 | |
| SCHEMBL21276824 | 0.74 | HRH3 (0.51) | HRH3HRH2HRH1EPHX2KCNH2 | |
| SCHEMBL21276814 | 0.74 | EPHX2 (0.51) | HRH3HRH2HRH1EPHX2KCNH2 | |
| SCHEMBL18763435 | 0.73 | ALDH1A1 (0.56) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169671-B1 | 1-(5-(TERT.-BUTYL)ISOXAZOL-3-YL)-3-(4-((PHENYL)ETHYNYL)PHENYL)UREA DERIVATIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATING CANCER | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |