Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076832 | 0.83 | LMNA (0.67) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL13797577 | 0.82 | LMNA (0.68) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL12942778 | 0.82 | LMNA (0.68) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL6026301 | 0.82 | LMNA (0.68) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL6025711 | 0.80 | LMNA (0.57) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL29942015 | 0.75 | STS (0.63) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL13797574 | 0.75 | LMNA (0.67) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL923334 | 0.75 | LMNA (0.67) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL12904926 | 0.75 | LMNA (0.67) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL13153839 | 0.75 | LMNA (0.67) | LMNAHSD17B10ESR1MAPTHSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013847-B1 | THERAPEUTICALLY ACTIVE ESTRATRIENTHIAZOLE DERIVATIVES AS INHIBITORS OF 17.BETA.-HYDROXY-STEROID DEHYDROGENASE, TYPE 1 | FORENDO PHARMA LTD (FI) | 2019-08-21 | — | — | EP | disclosed |