Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 16/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461242 | 0.82 | ADRB3 (0.62) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL10877587 | 0.80 | ADRB3 (0.54) | ADRB3ADRB1ADRB2KDM4EGAA | |
| SCHEMBL21278483 | 0.80 | ADRB3 (0.46) | ADRB3ADRB1 | |
| SCHEMBL4468428 | 0.80 | ADRB3 (0.59) | ADRB3ADRB1ADRB2 | |
| Hydrochloric Acid SCHEMBL6540262 | 0.79 | ADRB3 (0.63) | ADRB3ADRB1 | |
| Hydrochloric Acid SCHEMBL6554245 | 0.79 | ADRB3 (0.63) | ADRB3ADRB1 | |
| SCHEMBL21278195 | 0.79 | ADRB2 (0.50) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL6540912 | 0.78 | ADRB1 (0.52) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL6540916 | 0.78 | ADRB1 (0.52) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL21278193 | 0.78 | ADRB3 (0.43) | ADRB3ADRB1ADRB2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052099-B1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2019-08-21 | — | — | EP | disclosed |