Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | RARG | P13631 | 4/20 | 0.40 |
| ▸ | RARA | P10276 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447341 | 0.84 | NOTUM (0.63) | NOTUMGAARARBRARGRARA | |
| SCHEMBL17436030 | 0.78 | NOTUM (0.61) | NOTUMRARBRARGRARACYP26A1 | |
| SCHEMBL7404963 | 0.78 | KDM4E (0.51) | GAARARBRARGRARALMNA | |
| SCHEMBL3341864 | 0.76 | RARB (0.52) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL31396139 | 0.75 | NPY5R (0.48) | NOTUM | |
| SCHEMBL21279812 | 0.75 | ALDH1A1 (0.45) | NOTUMGAAALDH1A1SLC18A3SIGMAR1 | |
| SCHEMBL31330397 | 0.74 | SLC18A3 (0.41) | NOTUMSLC18A3SIGMAR1HDAC1HDAC8 | |
| SCHEMBL3114973 | 0.72 | RARB (0.46) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL20119174 | 0.70 | ALDH1A1 (0.56) | GAALMNAALDH1A1KDM4EMAPT | |
| SCHEMBL29932028 | 0.70 | SLC6A4 (0.40) | NOTUMLMNASLC18A3SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527561-A1 | NOVEL SUBSTITUTED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2019-08-21 | — | — | EP | disclosed |