Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2131477 | 0.81 | CHRM5 (0.43) | CYP2A6GRM5KDM4CKDM6BCCR1 | |
| SCHEMBL2130904 | 0.80 | DHFR (0.47) | GRM5CCR1CCR8CYP3A4CYP2C9 | |
| SCHEMBL10094541 | 0.80 | KCNA5 (0.39) | CYP2A6GRM5KCNA5SYKKDM4C | |
| SCHEMBL3409401 | 0.78 | KCNA5 (0.49) | CYP2A6GRM5KCNA5CHRNB2CHRNA4 | |
| SCHEMBL13443083 | 0.76 | KCNA5 (0.47) | CYP2A6GRM5KCNA5SYKKDM4C | |
| Hydrochloric Acid SCHEMBL4024971 | 0.76 | KCNA5 (0.47) | CYP2A6GRM5KCNA5CHRNB2CHRNA4 | |
| SCHEMBL13957483 | 0.73 | CFTR (0.42) | CYP2A6GRM5KCNA5 | |
| SCHEMBL12983823 | 0.73 | SYK (0.44) | GRM5KCNA5SYKKDM4CKDM6B | |
| SCHEMBL13367476 | 0.72 | KDM4C (0.44) | CYP2A6GRM5KCNA5KDM4C | |
| SCHEMBL5075470 | 0.72 | KCNA5 (0.50) | CYP2A6GRM5KCNA5CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101079-A1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101079-A1 | SUBSTITUTED 6-AMINO-NICOTINAMIDES AS KCNQ2/3 MODULATORS | KCNQ2, KCNQ1, KCNQ3 | CYP2A6 440/4885GRM5 1283/4885KCNA5 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.