Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 12/20 | 0.54 |
| ▸ | RAB9A | P51151 | 11/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13416333 | 0.81 | S1PR1 (0.78) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL14327903 | 0.79 | S1PR1 (0.71) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL13453337 | 0.79 | S1PR1 (0.71) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL1681421 | 0.76 | RAB9A (0.68) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL21282157 | 0.76 | S1PR1 (0.66) | S1PR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13453345 | 0.76 | S1PR1 (0.71) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL13469251 | 0.75 | S1PR1 (0.70) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL13417001 | 0.74 | S1PR1 (1.00) | S1PR1NPC1RAB9AS1PR3MAPT | |
| SCHEMBL17056149 | 0.73 | S1PR1 (0.63) | S1PR1NPC1RAB9AS1PR3SMN1; SMN2 | |
| SCHEMBL3739610 | 0.73 | S1PR1 (0.60) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190256492-A1 | ALPHA-SYNUCLEIN LIGANDS | WASHINGTON UNIVERSITY (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256492-A1 | ALPHA-SYNUCLEIN LIGANDS | SNCA, PARK7, LRRK2 | S1PR1 1435/4885NPC1 382/4885RAB9A 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.