Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21282219 | 0.92 | RAB9A (0.48) | S1PR1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL21273251 | 0.83 | S1PR1 (0.53) | S1PR1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL21282194 | 0.81 | NPC1 (0.56) | S1PR1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL21282179 | 0.80 | NPC1 (0.64) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21282172 | 0.80 | NPC1 (0.61) | S1PR1RAB9ANPC1SMN1; SMN2TSHR | |
| SCHEMBL21282193 | 0.78 | KDM4E (0.60) | RAB9ANPC1SMN1; SMN2TSHRMAPT | |
| SCHEMBL21282157 | 0.77 | S1PR1 (0.66) | S1PR1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL21273248 | 0.76 | RAB9A (0.65) | S1PR1RAB9ANPC1SMN1; SMN2TSHR | |
| SCHEMBL21282216 | 0.76 | NPC1 (0.54) | S1PR1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL21282220 | 0.75 | POLB (0.46) | S1PR1RAB9ANPC1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190256492-A1 | ALPHA-SYNUCLEIN LIGANDS | WASHINGTON UNIVERSITY (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256492-A1 | ALPHA-SYNUCLEIN LIGANDS | SNCA, PARK7, LRRK2 | S1PR1 1435/4885RAB9A 152/4885NPC1 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.