Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21274287 | 0.88 | KCNH2 (0.45) | SIGMAR1HTR6HTR7DRD4DRD3 | |
| SCHEMBL21281459 | 0.85 | DRD2 (0.51) | SIGMAR1HRH3HTR7DRD4DRD3 | |
| SCHEMBL21273960 | 0.85 | HRH3 (0.53) | HTR3AHTR6HRH3HTR7HTR3E | |
| SCHEMBL21273947 | 0.84 | KCNH2 (0.54) | HRH3HTR7DRD4DRD3 | |
| SCHEMBL21274049 | 0.84 | DRD2 (0.50) | SIGMAR1HRH3HTR7SLC6A2SLC6A4 | |
| SCHEMBL21274094 | 0.84 | PARP1 (0.50) | HTR7 | |
| SCHEMBL21274474 | 0.84 | PIM1 (0.44) | HRH3DRD4DRD3 | |
| SCHEMBL21281443 | 0.84 | HTR7 (0.44) | HRH3HTR7SLC6A4DRD3 | |
| SCHEMBL21274498 | 0.84 | HTR7 (0.43) | SIGMAR1HRH3HTR7DRD4SLC6A4 | |
| SCHEMBL21281583 | 0.83 | PARP1 (0.51) | HRH3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158731-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-08-22 | — | — | WO | disclosed |