Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 20/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 13/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21290766 | 1.00 | CD274 (0.40) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL24121619 | 0.87 | GNAI3 (0.46) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL14269728 | 0.85 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL21290617 | 0.85 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL21673405 | 0.85 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL25554382 | 0.84 | GNAI3 (0.44) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL22762715 | 0.84 | CD274 (0.41) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL6957136 | 0.81 | CD274 (0.39) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL6979357 | 0.81 | CD274 (0.36) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL25554386 | 0.80 | CD274 (0.38) | CD274PDCD1PDCD1LG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019160882-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-08-22 | — | — | WO | disclosed |