Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 8/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24121619 | 0.97 | GNAI3 (0.46) | GNAI3GNAO1GNAI1ALDH1A1TSHR | |
| SCHEMBL21290766 | 0.84 | CD274 (0.40) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL21290754 | 0.84 | CD274 (0.40) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL21673405 | 0.77 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL21290617 | 0.77 | CD274 (0.43) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL5175881 | 0.76 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1 | |
| SCHEMBL5872353 | 0.76 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1 | |
| SCHEMBL22201153 | 0.76 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1 | |
| SCHEMBL22190342 | 0.76 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1 | |
| SCHEMBL9646435 | 0.76 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159532-A1 | PARATHYROID HORMONE (PTH) RECEPTOR ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159532-A1 | PARATHYROID HORMONE (PTH) RECEPTOR ANTAGONISTS AND USES THEREOF | PTH1R, CALCR, VDR | GNAI3 1189/4885GNAO1 1221/4885GNAI1 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.