Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418348 | 1.00 | KDM4E (0.46) | KDM4EMEN1MAPTKMT2AEPHX1 | |
| SCHEMBL12217514 | 1.00 | KDM4E (0.46) | KDM4EMEN1MAPTKMT2AEPHX1 | |
| SCHEMBL12233213 | 0.85 | TSHR (0.38) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL12217720 | 0.85 | HSD11B1 (0.44) | KDM4EMEN1MAPTKMT2AEPHX1 | |
| SCHEMBL12218567 | 0.85 | HSD11B1 (0.44) | KDM4EMEN1MAPTKMT2AEPHX1 | |
| SCHEMBL12321230 | 0.84 | CTSK (0.59) | CTSK | |
| SCHEMBL3544236 | 0.84 | CTSK (0.59) | CTSK | |
| SCHEMBL3942865 | 0.84 | CTSK (0.59) | CTSK | |
| SCHEMBL28232383 | 0.83 | MCHR1 (0.41) | KDM4EMEN1MAPTKMT2ACTSK | |
| SCHEMBL8280845 | 0.82 | CA1 (0.47) | KDM4EMEN1MAPTKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019160882-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-08-22 | — | — | WO | disclosed |