Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | CASP7 | P55210 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15086126 | 0.87 | KDM4E (0.55) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL12611511 | 0.78 | NPC1 (0.79) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL29635856 | 0.77 | NPC1 (1.00) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL4386113 | 0.77 | NPC1 (1.00) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL15068821 | 0.75 | DGAT1 (0.48) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL24176816 | 0.74 | NPC1 (1.00) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL13478602 | 0.74 | NPC1 (0.72) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL4506209 | 0.74 | NPC1 (0.78) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL31022419 | 0.74 | NPC1 (0.78) | NPC1KDM4ERAB9ASMN1; SMN2HPGD | |
| SCHEMBL29582969 | 0.73 | MAPT (0.98) | NPC1KDM4ERAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2019-08-28 | — | — | EP | claimed |