SCHEMBL29582969

SCHEMBL29582969

CCN(CC)c1ccc2cc(-c3nc4ccccc4n3C)c(=O)oc2c1.[Ir+3]

nearest known ligand 0.98

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 0.98
▸ NPC1 O15118 8/20 0.98
▸ KDM4E B2RXH2 8/20 0.98
▸ KMT2A Q03164 8/20 0.98
▸ MEN1 O00255 7/20 0.98
▸ SMN1; SMN2 Q16637 6/20 0.98
▸ ALDH1A1 P00352 6/20 0.98
▸ HTT P42858 4/20 0.98
▸ CASP1 P29466 3/20 0.98
▸ CASP7 P55210 3/20 0.98
▸ ATM Q13315 3/20 0.98
▸ NPSR1 Q6W5P4 3/20 0.98
▸ HBB P68871 2/20 0.98
▸ HSD17B10 Q99714 2/20 0.98
▸ HCRTR1 O43613 1/20 0.98
▸ TSHR P16473 1/20 0.98
▸ TLR9 Q9NR96 1/20 0.98
▸ L3MBTL1 Q9Y468 1/20 0.98
▸ RAB9A P51151 7/20 0.67
▸ HPGD P15428 5/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357085 0.99 MAPT (1.00) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL457303 0.99 MAPT (1.00) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL28830001 0.98 MAPT (0.98) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL30874254 0.91 MAPT (0.85) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL24220026 0.91 MAPT (0.85) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL21753748 0.90 NPC1 (0.82) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL26493464 0.89 MAPT (0.81) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL2202346 0.88 MAPT (0.79) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL23450211 0.88 MAPT (0.79) MAPTNPC1KDM4EKMT2AMEN1
SCHEMBL4506209 0.87 NPC1 (0.78) MAPTNPC1KDM4EKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117384259-A Cell penetrating peptides based on influenza virus M2 proteins 中国医学科学院基础医学研究所 2024-01-12 — — CN claimed
CN-112912386-B Cell penetrating peptides based on influenza virus M2 proteins 中国医学科学院基础医学研究所 2023-10-20 — — CN claimed
US-20220169680-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2022-06-02 — — US claimed
US-20260146063-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-05-28 — — US disclosed
US-20260125426-A1 CYCLIC CELL-PENETRATING PEPTIDES AND USES THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-05-07 — — US disclosed
US-20260070948-A1 CYCLIC CELL-PENETRATING PEPTIDES WITH CARGO OHIO STATE INNOVATION FOUNDATION (US) 2026-03-12 — — US disclosed
US-20260070947-A1 CYCLIC CELL-PENETRATING PEPTIDE COMPOUNDS OHIO STATE INNOVATION FOUNDATION (US) 2026-03-12 — — US disclosed
US-20260008816-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-01-08 — — US disclosed
US-20260008813-A1 CELL-PENETRATING PEPTIDE COMPOUNDS OHIO STATE INNOVATION FOUNDATION (US) 2026-01-08 — — US disclosed
US-20260008812-A1 CELL-PENETRATING PEPTIDE COMPOUNDS OHIO STATE INNOVATION FOUNDATION (US) 2026-01-08 — — US disclosed
US-20260009759-A1 ANALYTE SENSOR DEXCOM, INC. (US) 2026-01-08 — — US disclosed
WO-2022178379-A1 CYCLIC CELL-PENETRATING PEPTIDES WITH THREE OR MORE HYDROPHOBIC RESIDUES OHIO STATE INNOVATION FOUNDATION (US) 2022-08-25 — — WO disclosed
US-11414455-B2 Toll-like receptor 2 ligands and methods of making and using thereof H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2022-08-16 — — US disclosed
US-20220214300-A1 MEMBRANE LAYERS FOR ANALYTE SENSORS DEXCOM, INC. (US) 2022-07-07 — — US disclosed
US-20220177523-A1 CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF ENTRADA THERAPEUTICS, INC. 2022-06-09 — — US disclosed
US-11352394-B2 Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof OHIO STATE INNOVATION FOUNDATION (US) 2022-06-07 — — US disclosed
US-11351222-B2 Di-sulfide containing cell penetrating peptides and methods of making and using thereof OHIO STATE INNOVATION FOUNDATION (US) 2022-06-07 — — US disclosed
US-20220169680-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2022-06-02 — — US disclosed
US-20220160819-A1 DI-SULFIDE CONTAINING CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-05-26 — — US disclosed
US-11262326-B2 Membrane layers for analyte sensors DEXCOM, INC. (US) 2022-03-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11352394-B2 Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof VIP, LNPEP, IAPP MAPT 4401/4885NPC1 850/4885KDM4E 4729/4885
US-20260008816-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF SLC3A2, SPPL2B, SLC7A1 MAPT 3571/4885NPC1 440/4885KDM4E 4278/4885
US-20260008812-A1 CELL-PENETRATING PEPTIDE COMPOUNDS SLC38A7, SLC7A1, SLC6A7 MAPT 1792/4885NPC1 211/4885KDM4E 3368/4885
US-20260146063-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF VIP, SLC7A1, SLC6A15 MAPT 2501/4885NPC1 490/4885KDM4E 3490/4885
US-20260125426-A1 CYCLIC CELL-PENETRATING PEPTIDES AND USES THEREOF SLC7A1, TAP1, SLC7A5 MAPT 1438/4885NPC1 46/4885KDM4E 3395/4885
US-20220177523-A1 CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF VIP, LNPEP, TAP1 MAPT 3736/4885NPC1 83/4885KDM4E 4839/4885
US-20260070947-A1 CYCLIC CELL-PENETRATING PEPTIDE COMPOUNDS SLC7A1, SLC38A7, SLC6A19 MAPT 1802/4885NPC1 240/4885KDM4E 3753/4885
US-20220160819-A1 DI-SULFIDE CONTAINING CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF IKBKE, IKBKB, SHARPIN MAPT 4355/4885NPC1 2926/4885KDM4E 3637/4885
US-11414455-B2 Toll-like receptor 2 ligands and methods of making and using thereof TLR2, TLR3, TLR4 MAPT 3681/4885NPC1 2343/4885KDM4E 3785/4885
US-20260070948-A1 CYCLIC CELL-PENETRATING PEPTIDES WITH CARGO SLC7A1, SLC38A7, SLC6A19 MAPT 2443/4885NPC1 528/4885KDM4E 3387/4885
US-11351222-B2 Di-sulfide containing cell penetrating peptides and methods of making and using thereof IKBKE, IKBKB, SHARPIN MAPT 4355/4885NPC1 2926/4885KDM4E 3637/4885
US-11262326-B2 Membrane layers for analyte sensors MGAM, UGDH, UNG MAPT 3334/4885NPC1 4328/4885KDM4E 4226/4885
US-20260008813-A1 CELL-PENETRATING PEPTIDE COMPOUNDS SLC7A1, SLC38A7, SLC6A19 MAPT 1661/4885NPC1 145/4885KDM4E 3019/4885
US-20260009759-A1 ANALYTE SENSOR EPCAM, SLC6A12, GJB2 MAPT 3692/4885NPC1 4840/4885KDM4E 1658/4885
US-20220214300-A1 MEMBRANE LAYERS FOR ANALYTE SENSORS MGAM, UGDH, UNG MAPT 3334/4885NPC1 4328/4885KDM4E 4226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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