Acetic Acid

Acetic Acid

SCHEMBL2129188

CC(=O)O.Cc1cc(CN)c(C)c(C)c1C

nearest known ligand 0.39

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.39
IMPDH2 P12268 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.33
ALOX15 P16050 1/20 0.32
LDHA P00338 1/20 0.32
LDHB P07195 1/20 0.32
PTGS1 P23219 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL436433 0.87 ALDH1A1 (0.36) ALDH1A1ALOX15
SCHEMBL31319534 0.87 ALDH1A1 (0.36) ALDH1A1ALOX15
Hydrochloric Acid SCHEMBL2965179 0.85 ALDH1A1 (0.34) ALDH1A1ALOX15
Water SCHEMBL10401165 0.85 ALDH1A1 (0.34) ALDH1A1ALOX15
SCHEMBL25949691 0.75 CYP3A4 (0.42) NPSR1IMPDH2SMN1; SMN2ALDH1A1ALOX15
SCHEMBL1259129 0.75 ALOX15 (0.49) NPSR1SMN1; SMN2ALOX15PTGS1
SCHEMBL30990555 0.75 ALOX15 (0.49) NPSR1SMN1; SMN2ALOX15PTGS1
SCHEMBL13343478 0.73 HTT (0.42) NPSR1ALOX15PTGS1
Phosphine SCHEMBL28245494 0.73 ALOX15 (0.47) NPSR1SMN1; SMN2ALOX15PTGS1
SCHEMBL28115102 0.72 CA1 (0.33) NPSR1KDM4EALDH1A1ALOX15LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037951-B1 PHOTOCHROMIC EPOXY RESIN COATING COMPOSITION PPG IND OHIO INC (US) 2005-11-16 EP claimed
US-6268055-B1 CURED OVERCOATING PPG INDUSTRIES OHIO, INC. 2001-07-31 US claimed
EP-1037951-A1 PHOTOCHROMIC EPOXY RESIN COATING COMPOSITION PPG Industries Ohio, Inc. (US) 2000-09-27 EP claimed
WO-1999029791-A1 PHOTOCHROMIC EPOXY RESIN COATING COMPOSITION PPG INDUSTRIES OHIO, INC. (US) 1999-06-17 WO claimed
EP-1952184-B1 PHOTOCHROMIC MULTIFOCAL OPTICAL ARTICLE TRANSITIONS OPTICAL INC (US) 2021-08-11 EP disclosed
US-8742012-B2 Thermosetting film-forming compositions that produce atrane-containing cured coatings PPG INDUSTRIES OHIO, INC. (US) 2014-06-03 US disclosed
WO-2014043434-A2 POLYEPOXIDE-POLYACID COATING COMPOSITIONS, RELATED COATING PROCESSES AND COATED SUBSTRATES PPG INDUSTRIES OHIO, INC. (US) 2014-03-20 WO disclosed
US-20140072716-A1 POLYEPOXIDE-POLYACID COATING COMPOSITIONS, RELATED COATING PROCESSES AND COATED SUBSTRATES PPG INDUSTRIES OHIO, INC. (US) 2014-03-13 US disclosed
US-20140072717-A1 POLYEPOXIDE-POLYACID COATING COMPOSITIONS, RELATED COATING PROCESSES AND COATED SUBSTRATES PPG INDUSTRIES OHIO, INC. (US) 2014-03-13 US disclosed
US-20120101189-A1 THERMOSETTING FILM-FORMING COMPOSITIONS THAT PRODUCE ATRANE-CONTAINING CURED COATINGS PPG INDUSTRIES OHIO, INC. (US) 2012-04-26 US disclosed
EP-1952184-A2 PHOTOCHROMIC MULTIFOCAL OPTICAL ARTICLE TRANSITIONS OPTICAL, INC. (US) 2008-08-06 EP disclosed
US-7261843-B2 A transparent polymeric (polycarbonate) substrate (lens) having a transparent photochromic organic polymeric (polyester) coating appended to the surface; abrasion resistant, antireflective coating affixed to a maleimide derivative-containing film TRANSITIONS OPTICAL, INC. (US) 2007-08-28 US disclosed
US-4917955-A TOP COAT HAVING CURING CATALYST TO CURE BOTH COATS PPG INDUSTRIES, INC. (US) 1990-04-17 US disclosed
US-4849283-A MULTILYAER-PIGMNETED BASE COAT, TRANSPARENT TOP COAT. PPG INDUSTRIES, INC. (US) 1989-07-18 US disclosed
EP-0305078-A2 Process for preparing colour-plus-clear coated articles using high solids coating compositions containing a polyepoxide and a copolymer of an alpha-olefin and an olefinically unsaturated monoanhydride PPG INDUSTRIES, INC. (US) 1989-03-01 EP disclosed
US-4764430-A Crosslinkable compositions containing polyepoxides and polyacid curing agents PPG INDUSTRIES, INC. (US) 1988-08-16 US disclosed
EP-0275138-A2 Crosslinkable compositions containing polyepoxides and polyacid curing agents PPG INDUSTRIES, INC. (US) 1988-07-20 EP disclosed
US-4681811-A AUTOMOTIVE TOP COAT PPG INDUSTRIES, INC. (US) 1987-07-21 US disclosed
US-4650718-A AUTOMOBILE FINISHES PPG INDUSTRIES, INC. (US) 1987-03-17 US disclosed
EP-0212457-A2 Color plus clear coatings employing polyepoxides and polyacid curing agents in the clear coat PPG INDUSTRIES, INC. (US) 1987-03-04 EP disclosed