Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 4/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127186 | 0.86 | KDM4E (0.47) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2128600 | 0.82 | ALDH1A1 (0.62) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2129123 | 0.81 | RAB9A (0.56) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2126379 | 0.81 | FFAR1 (0.51) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2127619 | 0.81 | RAB9A (0.55) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2127407 | 0.79 | RAB9A (0.53) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1691364 | 0.77 | RAB9A (0.60) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2127333 | 0.77 | KDM4E (0.47) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2129364 | 0.77 | FFAR1 (0.50) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1691504 | 0.76 | RAB9A (0.53) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129375-B1 | IMIDAZO[1,2-A]PYRIDINES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2012-04-25 | — | — | EP | claimed |