Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768772 | 0.85 | PLA2G10 (0.50) | FGFR1PLA2G10SLC22A12MEN1ALDH1A1 | |
| SCHEMBL31706999 | 0.81 | PLA2G10 (0.39) | FGFR1PLA2G10KDM4ESLC22A12JAK2 | |
| Bromide SCHEMBL31705674 | 0.80 | PLA2G10 (0.38) | FGFR1PLA2G10KDM4ESLC22A12PARP1 | |
| Bromide SCHEMBL31706328 | 0.80 | PLA2G10 (0.38) | FGFR1PLA2G10KDM4ESLC22A12PARP1 | |
| SCHEMBL31092758 | 0.79 | PLA2G10 (0.45) | PLA2G10KDM4EPARP1PDE4B | |
| SCHEMBL30568618 | 0.72 | HSP90AA1 (0.40) | FGFR1KDM4ESLC22A12ARJAK2 | |
| SCHEMBL28439515 | 0.71 | CNR2 (0.61) | ALDH1A1CNR2 | |
| SCHEMBL4411023 | 0.70 | ALDH1A1 (0.49) | FGFR1KDM4ESLC22A12MEN1ALDH1A1 | |
| SCHEMBL6513795 | 0.68 | MCL1 (0.56) | RPS6KA5FGFR1KDM4EALDH1A1CNR2 | |
| SCHEMBL14413693 | 0.68 | BAZ2B (0.46) | RPS6KA5FGFR1KDM4ESLC22A12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190263816-A1 | Tricyclic Compounds And Their Use As Phosphodiesterase Inhibitors | PFIZER INC. (US) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263816-A1 | Tricyclic Compounds And Their Use As Phosphodiesterase Inhibitors | PDE3B, PDE3A, PDE5A | RPS6KA5 3073/4885FGFR1 2213/4885PLA2G10 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.