Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768772 | 0.79 | PLA2G10 (0.50) | ALDH1A1TSHRHSD17B10RECQLMEN1 | |
| SCHEMBL297463 | 0.77 | PDE4B (0.50) | ALDH1A1TSHRMEN1KMT2APOLB | |
| SCHEMBL6513795 | 0.75 | MCL1 (0.56) | ALDH1A1HSD17B10FGFR1KDM4ETDP1 | |
| SCHEMBL29904566 | 0.75 | SLC22A12 (0.40) | ALDH1A1TSHRMEN1KMT2AFGFR1 | |
| SCHEMBL31706999 | 0.70 | PLA2G10 (0.39) | FGFR1KDM4EDAOSLC22A12L3MBTL1 | |
| SCHEMBL21292095 | 0.70 | RPS6KA5 (0.40) | ALDH1A1MEN1KMT2AFGFR1KDM4E | |
| SCHEMBL27758760 | 0.70 | ALDH1A1 (0.56) | ALDH1A1TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL29030290 | 0.70 | CNR2 (0.43) | ALDH1A1HSD17B10KMT2APOLBKDM4E | |
| Bromide SCHEMBL31705674 | 0.70 | PLA2G10 (0.38) | FGFR1KDM4EDAOSLC22A12L3MBTL1 | |
| Bromide SCHEMBL31706328 | 0.70 | PLA2G10 (0.38) | FGFR1KDM4EDAOSLC22A12L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264446-A9 | Condensed Pyridines as Kinase Inhibitors | PALAU PHARMA, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| US-20080318977-A1 | Condensed Pyridines as Kinase Inhibitors | PALAU PHARMA, S.A. (ES) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264446-A9 | Condensed Pyridines as Kinase Inhibitors | MAPK1, MAP4K2, MAP3K1 | ALDH1A1 2298/4885TSHR 3988/4885HSD17B10 3402/4885 |
| US-20080318977-A1 | Condensed Pyridines as Kinase Inhibitors | MAPK1, MAP4K2, MAP3K1 | ALDH1A1 2298/4885TSHR 3988/4885HSD17B10 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.