Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26248701 | 0.98 | CYP1A2 (0.38) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| SCHEMBL22422895 | 0.87 | KDM4E (0.34) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| Bromide SCHEMBL117943 | 0.83 | KDM4E (0.52) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| Bromide SCHEMBL653934 | 0.83 | KDM4E (0.52) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| SCHEMBL15344664 | 0.82 | TSHR (0.41) | CHRNA7CHRNB4CHRNA3CYP1A2KDM4E | |
| Hydrochloric Acid SCHEMBL3641370 | 0.81 | CHRNA7 (0.50) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| Bromide SCHEMBL3641371 | 0.81 | KDM4E (0.56) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| Bromide SCHEMBL653935 | 0.81 | CHRNA7 (0.50) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| Water SCHEMBL3646710 | 0.81 | CHRNA7 (0.50) | CHRNA7CHRNB4CHRNA3ACHEBCHE | |
| Bromide SCHEMBL3646711 | 0.81 | CHRNA7 (0.50) | CHRNA7CHRNB4CHRNA3ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043636-B2 | Method for producing triarylorganoborates | COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) | 2024-07-23 | — | — | US | disclosed |
| US-20240002409-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2024-01-04 | — | — | US | disclosed |
| US-11760765-B2 | Method for producing triarylorganoborates | COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) | 2023-09-19 | — | — | US | disclosed |
| US-11078218-B2 | Process for the production of triaryl organoborates | COVESTRO DEUTSCHLAND AG (DE) | 2021-08-03 | — | — | US | disclosed |
| US-20190276479-A1 | PROCESS FOR THE PRODUCTION OF TRIARYL ORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2019-09-12 | — | — | US | disclosed |
| US-20190263838-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240002409-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | KMO, COASY, CYP3A4 | ACHE 976/4885CHRM2 2050/4885CHRM1 1843/4885 |
| US-11078218-B2 | Process for the production of triaryl organoborates | OR10J3, CYP4F3, CYP4B1 | ACHE 2478/4885CHRM2 95/4885CHRM1 216/4885 |
| US-12043636-B2 | Method for producing triarylorganoborates | KMO, COASY, CYP3A4 | ACHE 976/4885CHRM2 2050/4885CHRM1 1843/4885 |
| US-20190263838-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | CYP3A4, CYP3A43, CYP4B1 | ACHE 534/4885CHRM2 1830/4885CHRM1 1749/4885 |
| US-11760765-B2 | Method for producing triarylorganoborates | CYP3A4, CYP3A43, CYP4B1 | ACHE 534/4885CHRM2 1830/4885CHRM1 1749/4885 |
| US-20190276479-A1 | PROCESS FOR THE PRODUCTION OF TRIARYL ORGANOBORATES | CYP1B1, CYP3A4, CYP4B1 | ACHE 1832/4885CHRM2 2058/4885CHRM1 1614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.