Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 13/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 3/20 | 0.39 |
| ▸ | IL1B | P01584 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326980 | 1.00 | CRBN (0.43) | CRBNIKZF3ABCB1ABCG2SMN1; SMN2 | |
| SCHEMBL26317758 | 0.95 | CRBN (0.47) | CRBNIKZF3SMN1; SMN2ALDH1A1TNF | |
| SCHEMBL26321489 | 0.95 | CRBN (0.47) | CRBNIKZF3SMN1; SMN2ALDH1A1TNF | |
| SCHEMBL2251468 | 0.94 | CRBN (0.43) | CRBNIKZF3SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL30670257 | 0.93 | CRBN (0.51) | CRBNIKZF3SMN1; SMN2ALDH1A1TNF | |
| SCHEMBL2255353 | 0.93 | CRBN (0.51) | CRBNIKZF3SMN1; SMN2ALDH1A1TNF | |
| SCHEMBL2252482 | 0.92 | CRBN (0.44) | CRBNIKZF3SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL2249873 | 0.91 | CRBN (0.43) | CRBNIKZF3SMN1; SMN2ALDH1A1TNF | |
| SCHEMBL30670264 | 0.91 | CRBN (0.43) | CRBNIKZF3SMN1; SMN2ALDH1A1TNF | |
| SCHEMBL2250128 | 0.91 | CRBN (0.45) | CRBNIKZF3SMN1; SMN2TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220047709-A1 | DEGRADERS OF WEE1 KINASE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | US | disclosed |
| US-10689366-B2 | Compounds for MALT1 degredation | CORNELL UNIVERSITY (US) | 2020-06-23 | — | — | US | disclosed |
| WO-2020069105-A1 | DEGRADERS OF WEE1 KINASE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |
| EP-3535254-A1 | COMPOUNDS FOR MALT1 DEGRADATION | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20190263785-A1 | COMPOUNDS FOR MALT1 DEGRADATION | CORNELL UNIVERSITY (US) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689366-B2 | Compounds for MALT1 degredation | CRBN, NFKB2, NFKB1 | CRBN 1/4885IKZF3 479/4885ABCB1 392/4885 |
| US-20190263785-A1 | COMPOUNDS FOR MALT1 DEGRADATION | CRBN, NFKB2, NFKB1 | CRBN 1/4885IKZF3 449/4885ABCB1 373/4885 |
| US-20220047709-A1 | DEGRADERS OF WEE1 KINASE | WEE1, WEE2, PPME1 | CRBN 553/4885IKZF3 2634/4885ABCB1 2650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.