Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17072684 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1RAPGEF4MAPTRAB9A | |
| SCHEMBL16220679 | 0.82 | SYK (0.43) | SMN1; SMN2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL21297275 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1RAPGEF4MAPTRAB9A | |
| SCHEMBL15830031 | 0.82 | SYK (0.43) | SMN1; SMN2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL17072652 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1RAPGEF4MAPTRAB9A | |
| SCHEMBL18466164 | 0.78 | CCR2 (0.36) | SMN1; SMN2ALDH1A1LMNAHDAC3HDAC8 | |
| SCHEMBL20252397 | 0.78 | CCR2 (0.35) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20045019 | 0.78 | CCR2 (0.35) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18466160 | 0.78 | CCR2 (0.36) | SMN1; SMN2ALDH1A1LMNAHDAC3HDAC8 | |
| Hydrochloric Acid SCHEMBL6602265 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1RAPGEF4MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10391089-B2 | PRMT5 inhibitors and uses therof | Epizyme, Inc. (US) | 2019-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10391089-B2 | PRMT5 inhibitors and uses therof | PRMT5, PRMT1, PRMT6 | SMN1; SMN2 1132/4885ALDH1A1 3384/4885RAPGEF4 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.