Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24283662 | 1.00 | MAPK1 (0.42) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL24283640 | 0.88 | MAPK1 (0.55) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL21298747 | 0.88 | MAPK1 (0.55) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL21298732 | 0.85 | ALDH1A1 (0.52) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL24283843 | 0.85 | ALDH1A1 (0.52) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL21298748 | 0.85 | GABRA1 (0.59) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL24283642 | 0.84 | MAPK1 (0.42) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL24283651 | 0.83 | ALDH1A1 (0.44) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL28646915 | 0.82 | ALDH1A1 (0.43) | MAPK1ALDH1A1TDP1GABRA1GABRB2 | |
| SCHEMBL21298728 | 0.81 | CYP3A4 (0.46) | MAPK1ALDH1A1TDP1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360863-B1 | ETOMIDATE DERIVATIVE AND INTERMEDIATE, PREPARATION METHOD AND USE THEREOF | JIANGSU NHWALUOKANG PHARMACEUTICAL RES AND DEVELOPMENT CO LTD (CN) | 2022-04-20 | — | — | EP | disclosed |
| CN-113880770-A | Etomidate derivative and intermediate, preparation method and application thereof | 江苏恩华络康药物研发有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-108349906-B | Etomidate derivative and intermediate, preparation method and application thereof | 江苏恩华络康药物研发有限公司 | 2021-11-02 | — | — | CN | disclosed |
| US-10392352-B2 | Etomidate derivative and intermediate, preparation method and use thereof | JIANGSU NHWALUOKANG PHARMCEUTICAL RESEARCH AND DEVELOPMENT CO., LTD. (CN) | 2019-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392352-B2 | Etomidate derivative and intermediate, preparation method and use thereof | CYP4A11, CYP3A43, ETV1 | MAPK1 381/4885ALDH1A1 1107/4885TDP1 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.