Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23212270 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL31002588 | 0.90 | GPBAR1 (0.43) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL24966171 | 0.90 | ALDH1A1 (0.48) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL24966228 | 0.88 | ALDH1A1 (0.47) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL29186214 | 0.88 | ALDH1A1 (0.47) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL29186212 | 0.88 | ALDH1A1 (0.47) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL24966229 | 0.86 | ALDH1A1 (0.45) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL21298717 | 0.86 | MAPK1 (0.55) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL24966235 | 0.86 | ALDH1A1 (0.45) | ALDH1A1TDP1MEN1HPGDKMT2A | |
| SCHEMBL22696908 | 0.85 | MAPK1 (0.45) | ALDH1A1TDP1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026724-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF | CHENGDU MFS PHARMA. CO., LTD. (CN) | 2023-01-26 | — | — | US | disclosed |
| CN-112174890-B | Ketone-substituted heterocyclic compounds and their anesthetic action | 成都麻沸散医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3360863-B1 | ETOMIDATE DERIVATIVE AND INTERMEDIATE, PREPARATION METHOD AND USE THEREOF | JIANGSU NHWALUOKANG PHARMACEUTICAL RES AND DEVELOPMENT CO LTD (CN) | 2022-04-20 | — | — | EP | disclosed |
| CN-113880770-A | Etomidate derivative and intermediate, preparation method and application thereof | 江苏恩华络康药物研发有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-108349906-B | Etomidate derivative and intermediate, preparation method and application thereof | 江苏恩华络康药物研发有限公司 | 2021-11-02 | — | — | CN | disclosed |
| WO-2021068943-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF | 成都麻沸散医药科技有限公司 | 2021-04-15 | — | — | WO | disclosed |
| CN-112174890-A | Ketone-substituted heterocyclic compounds and their anesthetic action | 成都麻沸散医药科技有限公司 | 2021-01-05 | — | — | CN | disclosed |
| US-10392352-B2 | Etomidate derivative and intermediate, preparation method and use thereof | JIANGSU NHWALUOKANG PHARMCEUTICAL RESEARCH AND DEVELOPMENT CO., LTD. (CN) | 2019-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026724-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF | CYP21A2, CYP11B1, CYP11B2 | ALDH1A1 413/4885TDP1 3560/4885MEN1 2865/4885 |
| US-10392352-B2 | Etomidate derivative and intermediate, preparation method and use thereof | CYP4A11, CYP3A43, ETV1 | ALDH1A1 1107/4885TDP1 867/4885MEN1 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.