Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 13/20 | 0.61 |
| ▸ | MME | P08473 | 11/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | PLAT | P00750 | 2/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688341 | 0.82 | ECE1 (0.63) | ECE1MMEMMP8MMP14ACE2 | |
| SCHEMBL16856590 | 0.82 | ECE1 (0.58) | ECE1MMEMMP8MMP14ACE2 | |
| SCHEMBL28101997 | 0.82 | ECE1 (0.58) | ECE1MMEMMP8MMP14ACE2 | |
| SCHEMBL7291199 | 0.80 | ECE1 (0.61) | ECE1MMEACE2F2PLAU | |
| SCHEMBL14334539 | 0.80 | ECE1 (0.63) | ECE1MMEACE2F2PLAU | |
| SCHEMBL7328702 | 0.80 | ECE1 (0.63) | ECE1MMEACE2F2PLAU | |
| SCHEMBL7716999 | 0.80 | ECE1 (0.60) | ECE1MMEACE2F2PLAU | |
| SCHEMBL10958149 | 0.79 | ECE1 (0.59) | ECE1MMEACE2F2PLAU | |
| Bromide SCHEMBL1436853 | 0.79 | ECE1 (0.59) | ECE1MMEACE2F2PLAU | |
| SCHEMBL7397375 | 0.78 | ECE1 (0.59) | ECE1MMEACE2F2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082877-B1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2019-08-28 | — | — | EP | disclosed |