Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 13/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15069373 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL21301201 | 0.87 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15069843 | 0.87 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15068756 | 0.82 | RAB9A (0.46) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15068984 | 0.81 | NPC1 (0.43) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15068676 | 0.80 | NPC1 (0.44) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15065910 | 0.80 | NPC1 (0.44) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15069060 | 0.80 | ALDH1A1 (0.51) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL21301204 | 0.78 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15068910 | 0.78 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2019-08-28 | — | — | EP | disclosed |