Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 7/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.38 |
| ▸ | CFTR | P13569 | 6/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211872 | 0.90 | CNR1 (0.40) | CNR1EGLN2EGLN1CFTRCNR2 | |
| SCHEMBL14856735 | 0.88 | CNR1 (0.36) | CNR1P2RX7PSDCYP1A2 | |
| SCHEMBL213032 | 0.88 | CNR1 (0.44) | CNR1CFTRCNR2CYP1A2 | |
| SCHEMBL212569 | 0.86 | CNR1 (0.54) | CNR1CFTRCNR2 | |
| SCHEMBL214825 | 0.86 | CNR1 (0.40) | CNR1CFTRCNR2ADORA2ACYP1A2 | |
| SCHEMBL213908 | 0.84 | NPY2R (0.37) | CNR1EGLN2EGLN1CFTRCNR2 | |
| SCHEMBL4056978 | 0.80 | KMO (0.46) | PSDADORA2ACYP1A2 | |
| SCHEMBL213341 | 0.79 | CNR1 (0.43) | CNR1EGLN1CFTRCNR2CYP1A2 | |
| SCHEMBL214132 | 0.79 | CNR1 (0.51) | CNR1CNR2 | |
| SCHEMBL14856824 | 0.78 | CNR1 (0.36) | CNR1CNR2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | claimed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | disclosed |