Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.50 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929873 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL6196424 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL21148134 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL6198016 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL6196431 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL21311255 | 0.84 | OPRM1 (0.59) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL21311238 | 0.82 | RPS6KB1 (0.47) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL21311237 | 0.82 | RPS6KB1 (0.47) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL9685823 | 0.81 | RPS6KB1 (0.47) | RPS6KB1ROCK1PRKACAGSK3BNOS2 | |
| SCHEMBL21311046 | 0.81 | RPS6KB1 (0.50) | RPS6KB1ROCK1PRKACAGSK3BNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174245-B2 | Benzimidazole compounds and derivatives as EGFR inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| US-20200377476-A1 | NEW BENZIMIDAZOLE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-12-03 | — | — | US | disclosed |
| WO-2019162323-A1 | NEW BENZIMIDAZOLE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377476-A1 | NEW BENZIMIDAZOLE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | EGFR, ERBB2, ERBB3 | RPS6KB1 357/4885ROCK1 651/4885PRKACA 361/4885 |
| US-11174245-B2 | Benzimidazole compounds and derivatives as EGFR inhibitors | EGFR, ERBB2, ERBB3 | RPS6KB1 412/4885ROCK1 504/4885PRKACA 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.