Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.45 |
| ▸ | PRKACA | P17612 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11213404 | 0.98 | RPS6KB1 (0.46) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL6196424 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL21148134 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL6198016 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL6196431 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL2929873 | 0.85 | RPS6KB1 (0.58) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL21311255 | 0.84 | OPRM1 (0.59) | RPS6KB1ROCK1NOS2OPRM1OPRD1 | |
| SCHEMBL9876669 | 0.81 | TP53 (0.46) | RPS6KB1ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL11791438 | 0.81 | OPRM1 (0.45) | RPS6KB1ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL7587030 | 0.81 | CCR5 (0.54) | RPS6KB1ROCK1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752615-B2 | Spirocyclic containing compounds and pharmaceutical uses thereof | GB005, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190263790-A1 | SPIROCYCLIC CONTAINING COMPOUNDS AND PHARMACEUTICAL USES THEREOF | GB005, INC. | 2019-08-29 | — | — | US | disclosed |
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10752615-B2 | Spirocyclic containing compounds and pharmaceutical uses thereof | TEC, ITK, TXK | RPS6KB1 593/4885ROCK1 356/4885NOS2 3982/4885 |
| US-20190263790-A1 | SPIROCYCLIC CONTAINING COMPOUNDS AND PHARMACEUTICAL USES THEREOF | TEC, ITK, TXK | RPS6KB1 593/4885ROCK1 356/4885NOS2 3982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.