Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 5/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095848 | 0.87 | MGLL (0.42) | HTR2CSLC6A4MGLLSIGMAR1 | |
| SCHEMBL20095849 | 0.87 | MGLL (0.42) | HTR2CSLC6A4MGLLSIGMAR1 | |
| SCHEMBL20096106 | 0.87 | MGLL (0.42) | HTR2CSLC6A4MGLLSIGMAR1 | |
| SCHEMBL21311628 | 0.83 | HTR2C (0.50) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL21311808 | 0.83 | HTR2C (0.50) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL21312221 | 0.81 | MGLL (0.39) | HTR2AHTR2CHTR2BHRH3SLC6A4 | |
| SCHEMBL20095514 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BHRH3SLC6A4 | |
| SCHEMBL20095714 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BHRH3SLC6A4 | |
| SCHEMBL3976082 | 0.81 | DRD2 (0.55) | HTR2AHTR2CHTR2BHRH3DRD2 | |
| SCHEMBL30169622 | 0.81 | DRD2 (0.55) | HTR2AHTR2CHTR2BHRH3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |