Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DCK | P27707 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21313148 | 0.91 | TLR8 (0.46) | ADORA2AAPPTLR8PIK3CDPIK3CA | |
| SCHEMBL21313198 | 0.91 | APP (0.43) | ADORA2AAPPTLR8ADORA1PIK3CD | |
| SCHEMBL16223004 | 0.88 | APP (0.40) | ADORA2AAPPTLR8ADORA1PIK3CD | |
| SCHEMBL21313250 | 0.87 | HRH2 (0.49) | ADORA2AAPPTLR8ADORA1FYN | |
| SCHEMBL21313266 | 0.83 | ADORA2A (0.40) | ADORA2AAPPTLR8ADORA1PIK3CD | |
| SCHEMBL16223129 | 0.83 | ADK (0.44) | ADORA2AAPPADORA1ADORA2BPIK3CD | |
| SCHEMBL16223085 | 0.83 | JAK2 (0.39) | ADORA2AAPPTLR8ADORA1PIK3CD | |
| SCHEMBL21313218 | 0.83 | ADORA2A (0.44) | ADORA2AAPPTLR8ADORA1PIK3CD | |
| SCHEMBL16223126 | 0.83 | ADORA2A (0.40) | ADORA2AAPPTLR8ADORA1ADORA2B | |
| SCHEMBL21313255 | 0.82 | ADORA2A (0.44) | ADORA2AAPPNAMPTADORA1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |