Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21313198 | 0.90 | APP (0.43) | ADORA2AADORA1APPFYNTLR8 | |
| SCHEMBL21313148 | 0.88 | TLR8 (0.46) | ADORA2AAPPFYNTLR8PIK3CD | |
| SCHEMBL16223004 | 0.87 | APP (0.40) | ADORA2AADORA1APPFYNTLR8 | |
| SCHEMBL16223129 | 0.84 | ADK (0.44) | ADORA2AADORA1APPPIK3CDPIK3CA | |
| SCHEMBL21313188 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1APPFYNTLR8 | |
| SCHEMBL16223017 | 0.83 | ADORA2A (0.47) | ADORA2AADORA1TLR8DRD2HTR6 | |
| SCHEMBL16223135 | 0.82 | ADORA2A (0.58) | ADORA2AADORA1TLR8DRD2HTR6 | |
| SCHEMBL21313150 | 0.82 | ADORA2A (0.44) | ADORA2AADORA1APPFYNPIK3CD | |
| SCHEMBL16223085 | 0.82 | JAK2 (0.39) | ADORA2AADORA1APPFYNTLR8 | |
| SCHEMBL16223126 | 0.82 | ADORA2A (0.40) | ADORA2AADORA1APPFYNTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |